The Postdoctoral Fellow position is immediately available in the Barbieri laboratory to study the molecular mechanisms regulating tumor initiation and differentiation in neuroblastoma, a pediatric cancer arising from sympatho-adrenal neural crest cells. The lab aims at understanding how the epigenetic regulator CHAF1A drives undifferentiated, chemo-refractory, and metabolically distinct tumors, and developing novel approaches to intervention for high-risk neuroblastoma. Specifically, the lab is focused on understanding how the epigenetic changes induced by CHAF1A drive neuroblastoma oncogenesis, with particular emphasis on studies at the intersection of epigenetics, cell differentiation, and cell metabolism (Front Cell Dev Biol 2026; Trends Mol Med 2026, Cancer Discovery 2024; Nature Communications 2022, Nature Communications 2021; Advanced Science 2021). The Postdoctoral Fellow will use a combination of various cell and molecular biology approaches (including CRISPR-Cas9 gene editing, ChIP-seq, Co-IP, RNA-seq, ATAC-seq, metabolomics, metabolic tracing and differentiation assays), as well as different tumors models (transgenic, xenograft/PDX and syngeneic) and neural crest models to elucidate the epigenetic changes induced by CHAF1A during neuroblastoma initiation and progression.
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